The township lies on the Harbour Line and is the last stop in the city before Navi Mumbai . After Mankhurd, trains cross the Vashi Bridge before reaching Vashi , in Navi Mumbai . Mankhurd also has a railway line run by the Bombay Port Trust.
Unlike many of the railway stations in Mumbai, which have 'east' and 'west' sides, this station has a 'north' and 'south' side on either side of the railway track. Bhabha Atomic Research Centre's employee township "Anushakti Nagar ", Naval Employee's Township, Mandala and Trombay are some nearby accessible places from the south side of this train station and P.M.G.P. Colony, Mohite-Patil Nagar, Sonapur, Mandala are some nearby accessible places from North side. BEST (Brihanmumbai Electric Supply and Transport) public buses serve this station. Metered and non-metered auto rickshaws are common sight outside the station. There is a civil colony- SPDC Colony located about 2 kilometres away from the station road.
The place is the closest to the atomic reactor and the railway station was primarily built to cater to the atomic reactor logistics. Majority of Mankhurd's population is below the poverty line.